

Thus, 3D bioprinting is the technology of layer-by-layer fabrication of 3D tissue and organ constructs according to the assumed digital model using living cells as printing material.įor now, however, the lack of cell material is one of the limiting factors for bioprinting technology development. Due to these features, 3D bioprinting technology appears to be an extremely promising approach in the fabrication of cell material-containing biomimetic scaffolds (substrates) that serves as the basis for the creation of living and functional 3D constructs for the benefit of regenerative medicine. The implementation of an automated additive process eases the fabrication of 3D products on the basis of high-precision control of their architecture, external shape, inner geometry of pores, and the correlation between high reproducibility and repeatability.

have proposed the method of extrusion 3D bioprinting with the use of tissue spheroids as “building blocks”. Boland has suggested the bioprinting method based on traditional two-dimensional (2D) inkjet technology in 2003. Nowadays, several technologies are united by the term “3D printing:” Fused deposition modeling SLA, digital light processing ColorJet printing multiple jet modeling selective laser sintering selective laser melting and direct metal laser sintering.

This work was the first in the area of 3D printing techniques. Hull has received the patent for photopolymerization-based stereolithography (SLA) technology in 1986. Three-dimensional (3D) printing is the technology of fast prototyping and additive manufacturing used to create the complex architecture of high accuracy through stage process of product construction according to the specified digital mode.
